Publications

 

 

 

 

 

dOFM


Bodenlenz M, Aigner B, Dragatin C, Liebenberger L, Zahiragic S, Höfferer C, et al. Clinical applicability of dOFM devices for dermal sampling. Skin Res Technol 2013;19:474–83. doi:10.1111/srt.12071.


Bodenlenz M, Dragatin C, Liebenberger L, Tschapeller B, Boulgaropoulos B, Augustin T, et al. Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution. Pharm Res 2016;33:2229–38. doi:10.1007/s11095-016-1960-y.


Dragatin C, Polus F, Bodenlenz M, Calonder C, Aigner B, Tiffner KI, et al. Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion. Exp Dermatol 2016;2:157–9. doi:10.1111/exd.12863.


Schwingenschuh S, Scharfetter H, Martinsen OG, Boulgaropoulos B, Augustin T, Tiffner K, et al. Assessment of skin permeability to topically applied drugs by skin impedance and admittance. Physiol Meas 2017. doi:10.1088/1361-6579/aa904e.


Bodenlenz M, Tiffner KI, Raml R, Augustin T, Dragatin C, Birngruber T, et al. Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence. Clin Pharmacokinet 2017;56:91–8. doi:10.1007/s40262-016-0442-z.


Kolbinger F, Loesche C, Valentin M-A, Jiang X, Cheng Y, Jarvis P, et al. β-defensin-2 is a responsive biomarker of IL-17A-driven skin pathology in psoriasis. J Allergy Clin Immunol 2016. doi:10.1016/j.jaci.2016.06.038.


Schimek D, Raml R, Francesconi KA, Bodenlenz M, Sinner FM. Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation. Biomed Chromatogr 2018;32:e4194. doi:10.1002/bmc.4194.


Tiffner KI, Kanfer I, Augustin T, Raml R, Raney SG, Sinner FM. A comprehensive approach to qualify and validate the essential parameters of an in vitro release test (IVRT) method for acyclovir cream, 5%. Int J Pharm 2018;535:217–27. doi:10.1016/j.ijpharm.2017.09.049.


Terlecki-Zaniewicz L, Pils V, Bobbili MR, Lämmermann I, Perrotta I, Grillenberger T, et al. Extracellular Vesicles in Human Skin: Cross-Talk from Senescent Fibroblasts to Keratinocytes by miRNAs. J Invest Dermatol 2019. doi:10.1016/j.jid.2019.05.015.

 


 

cOFM


Altendorfer-Kroath T, Schimek D, Eberl A, Rauter G, Ratzer M, Raml R, et al. Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances. J Neurosci Methods 2019;311:394–401. doi:10.1016/j.jneumeth.2018.09.024.


Birngruber T, Ghosh A, Perez-Yarza V, Kroath T, Ratzer M, Pieber TR, et al. Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier. Clin Exp Pharmacol Physiol 2013;40:864–71. doi:10.1111/1440-1681.12174.


Birngruber T, Raml R, Gladdines W, Gatschelhofer C, Gander E, Ghosh A, et al. Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,(®) /Doxil(®) -A Cerebral Open Flow Microperfusion Pilot Study. J Pharm Sci 2014;103:1945–8. doi:10.1002/jps.23994.


Birngruber T, Sinner FM. Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue. Drug Discov Today Technol 2016;20:19–25. doi:10.1016/j.ddtec.2016.07.003.


Eberl A, Altendorfer-Kroath T, Kollmann D, Birngruber T, Sinner FM, Raml R, et al. Determination of 2H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography – quadrupole-mass-spectrometry. Anal Biochem 2016;509:130–4. doi:10.1016/j.ab.2016.07.010.


Kleinert M, Kotzbeck P, Altendorfer-Kroath T, Birngruber T, Tschöp MH, Clemmensen C. Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice. Mol Metab 2018;13:77–82. doi:10.1016/j.molmet.2018.04.008.


Hummer J, Altendorfer-Kroath T, Birngruber T. Cerebral Open Flow Microperfusion to Monitor Drug Transport Across the Blood-Brain Barrier. Curr Protoc Pharmacol 2019:e60.

 


 

aOFM


Bodenlenz M, Ellmerer M, Schaupp L, Jacobsen L V, Plank J, Brunner GA, et al. Bioavailability of insulin detemir and human insulin at the level of peripheral interstitial fluid in humans, assessed by open-flow microperfusion. Diabetes Obes Metab 2015;12:1166–72. doi:10.1111/dom.12551.


Höfferer C, Tutkur D, Fledelius C, Brand CL, Alsted TJ, Damgaard J, et al. Open flow microperfusion: pharmacokinetics of human insulin and insulin detemir in the interstitial fluid of subcutaneous adipose tissue. Diabetes, Obes Metab 2015;17:121–7. doi:10.1111/dom.12394.


Tiffner K, Boulgaropoulos B, Höfferer C, Birngruber T, Porksen N, Linnebjerg H, et al. Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion. Diabetes Technol Ther 2017;19:305–14. doi:10.1089/dia.2016.0384.


Altendorfer-Kroath T, Schwingenschuh S, Schondorff-Kruse P, Heschel M, Sinner F, Birngruber T. Insulin distribution in human adipose tissue via a novel insulin infusion catheter. Diabetes Technol Ther 2019:dia.2019.0195. doi:10.1089/dia.2019.0195.